Alterations in the expression of tumor necrosis factor-alpha in the uveitis with optic nerve inflammation

N.V. Panchenko, Dr Sc (Med)

M.N. Samofalova, DM

E.N. Gonchar, DM

D.O. Prikhod’ko, DM

G.S. Arustamova, DM

A.V. Lytvyshchenko, DM

Department of Ophthalmology, Kharkiv National Medical University

Kharkiv, Ukraine

E-mail: panchenko0802@gmail.com

Purpose: To assess serum levels of tumor necrosis factor-alpha (TNF-α) in uveitis patients with optic nerve inflammation (ONI).

Materials and Methods: A retrospective evaluation of 132 patients who underwent examination and treatment for uveitis with ONI was performed. A commercially available enzyme-linked immunosorbent assay kit was used to measure serum TNF-α levels. Serum samples of 30 healthy donors were used as controls.

Results: Serum TNF-α levels in uveitis patients with ONI were 3.8 times higher compared to those in healthy controls (15.8 ± 1.02 pg/mL and 4.1 ± 1.52 pg/mL, respectively, p < 0.05). The highest increase in serum TNF-α levels compared to controls was seen in intermediate uveitis.

Conclusion: Serum TNF-α levels in active period of uveitis with ONI were found to be statistically significantly increased compared to those in controls. This finding provides the rationale for the use of anti-TNF-α agents for the treatment of uveitis with optic nerve inflammation.

Key words: uveitis with optic nerve inflammation, tumor necrosis factor-alpha



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